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The active drug intermediate compound 2-cyano-3-methylpyride (CMP) was being manufactured by batch reaction of picoline-N-oxide (PNO) with diethylcarbamoyl chloride (DECC) in acetone (C3H6O). On the day of the incident, a glass-lined, mechanically agitated carbon steel reactor suffered significant deformation and a blowout of the manway gasket and solids addition chute top cover, resulting in the release of reactants at high temperature and pressure. Two operators were present at the time. Both were severely injured. The reactor and associated hardware suffered significant damage. The blast wave from the vessel failure also caused extensive damage to the 4-storey building.
Ask yourself and your crew:
- How can something like this happen here (e.g. on our site)?
- What safety measures (i.e. procedures, controls/barriers) do we have in place to mitigate the risk?
- How do we know the risk controls/barriers are working?
- What improvements or changes should we make to the procedures, controls/barriers or the way we work?
Original content courtesy of IChemE Safety Centre
